V-GLUTATION PLUS — Glutathione, Vitamin C & Curcumin (9 citations)
[1] Lysine Carboxymethyl Cysteinate, as a Topical Glutathione Precursor, Protects Against Oxidative Stress and UVB Radiation-Induced Skin Damage.
Gao P, Xiao X, Cui X et al. · Antioxidants (Basel, Switzerland) · 2025
Lysine carboxymethyl cysteinate (LCC) is a synthetic substance obtained via lysine salification of S-carboxymethyl-cysteine. LCC has emerged as a promising glutathione (GSH) precursor. In this study, ...
PubMed PMID: 40427487
[2] Randomized controlled trial of oral glutathione supplementation on body stores of glutathione.
Richie JP, Nichenametla S, Neidig W et al. · European journal of nutrition · 2015
Glutathione (GSH), the most abundant endogenous antioxidant, is a critical regulator of oxidative stress and immune function. While oral GSH has been shown to be bioavailable in laboratory animal mode...
PubMed PMID: 24791752
[3] Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function.
Sinha R, Sinha I, Calcagnotto A et al. · European journal of clinical nutrition · 2018
Glutathione (GSH) is the most abundant endogenous antioxidant and a critical regulator of oxidative stress. Maintenance of optimal tissues for GSH levels may be an important strategy for the preventio...
PubMed PMID: 28853742
[4] Efficacy of TurmiZn, a Metallic Complex of Curcuminoids-Tetrahydrocurcumin and Zinc on Bioavailability, Antioxidant, and Cytokine Modulation Capabi...
DuBourdieu D, Talukder J, Srivastava A et al. · Molecules (Basel, Switzerland) · 2023
Complexes of curcumin with metals have shown much-improved stability, solubility, antioxidant capability, and efficacy when compared to curcumin. The present research investigates the relative bioavai...
PubMed PMID: 36838654
[5] Positive Tetrahydrocurcumin-Associated Brain-Related Metabolomic Implications.
Josifovska S, Panov S, Hadzi-Petrushev N et al. · Molecules (Basel, Switzerland) · 2023
Tetrahydrocurcumin (THC) is a metabolite of curcumin (CUR). It shares many of CUR's beneficial biological activities in addition to being more water-soluble, chemically stable, and bioavailable compar...
PubMed PMID: 37175144
[6] The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress.
Raghu G, Berk M, Campochiaro PA et al. · Current neuropharmacology · 2021
Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing tripeptide gluta...
PubMed PMID: 33380301
[7] N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why.
Aldini G, Altomare A, Baron G et al. · Free radical research · 2018
The main molecular mechanisms explaining the well-established antioxidant and reducing activity of N-acetylcysteine (NAC), the N-acetyl derivative of the natural amino acid l-cysteine, are summarised ...
PubMed PMID: 29742938
[8] Antioxidants, oxidative damage and oxygen deprivation stress: a review.
Blokhina O, Virolainen E, Fagerstedt KV · Annals of botany · 2003
Oxidative stress is induced by a wide range of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), herbicide action and oxygen shortage. Oxygen deprivation stress i...
PubMed PMID: 12509339
[9] Dehydroascorbate reduction.
Wells WW, Xu DP · Journal of bioenergetics and biomembranes · 1994
Dehydroascorbic acid is generated in plants and animal cells by oxidation of ascorbic acid. The reaction is believed to occur by the one-electron oxidation of ascorbic acid to semidehydroascorbate rad...
PubMed PMID: 7844111
VITALAGE COLLAGEN — Collagen, Resveratrol & Hyaluronic Acid (12 citations)
[1] A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study.
Bolke L, Schlippe G, Gerß J et al. · Nutrients · 2019
The purpose of this randomized, placebo-controlled, blind study was to investigate the effects of the drinkable nutraceutical ELASTEN
PubMed PMID: 31627309
[2] Low-molecular-weight collagen peptides supplement promotes a healthy skin: A randomized, double-blinded, placebo-controlled study.
Seong SH, Lee YI, Lee J et al. · Journal of cosmetic dermatology · 2024
Oral collagen peptides supplementation was reported to improve skin integrity and counteract skin aging.
PubMed PMID: 37822045
[3] Oral Administration of Protease-Soluble Chicken Type II Collagen Ameliorates Anterior Cruciate Ligament Transection-Induced Osteoarthritis in Rats.
Chen NF, Lin YY, Yao ZK et al. · Nutrients · 2023
This study investigated whether oral supplementation with protease-soluble chicken type II collagen (PSCC-II) mitigates the progression of anterior cruciate ligament transection (ACLT)-induced osteoar...
PubMed PMID: 37630779
[4] Valorisation of fish scales and bones: a sustainable source of bioactive proteins and collagen for nutraceuticals.
Jeyachandran S, Aman M · Bioresources and bioprocessing · 2025
Fish scales and bones, traditionally regarded as low-value seafood by-products, represent abundant and sustainable sources of collagen and bioactive proteins with high nutraceutical potential. These t...
PubMed PMID: 41335283
[5] Nutraceutical activation of Sirt1: a review.
DiNicolantonio JJ, McCarty MF, O'Keefe JH · Open heart · 2022
The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several complementary effects on cellular function that are favourable to healthspan; it is often thought of as ...
PubMed PMID: 36522127
[6] Anti-Aging Drugs - Prospect of Longer Life?
Klimova B, Novotny M, Kuca K · Current medicinal chemistry · 2018
Aging is a natural part of human life. However, recent discoveries indicate that pharmacological approaches used for the improvement and possibly, for the delay of the aging process, might shed a new ...
PubMed PMID: 29189123
[7] The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized...
Asserin J, Lati E, Shioya T et al. · Journal of cosmetic dermatology · 2015
Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wi...
PubMed PMID: 26362110
[8] Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction.
Amin P, Sarabi A, Choe S et al. · Journal of drugs in dermatology : JDD · 2025
Hyaluronic acid (HA) is a key component naturally present in the skin and is commonly used in skincare formulations and dermal fillers. Recently, there has been growing interest in oral HA supplementa...
PubMed PMID: 40911749
[9] Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review.
Davinelli S, Nielsen ME, Scapagnini G · Nutrients · 2018
Astaxanthin, a xanthophyll carotenoid, is a secondary metabolite naturally synthesized by a number of bacteria, microalgae, and yeasts. The commercial production of this pigment has traditionally been...
PubMed PMID: 29690549
[10] Effects of Astaxanthin Supplementation on Skin Health: A Systematic Review of Clinical Studies.
Ng QX, De Deyn MLZQ, Loke W et al. · Journal of dietary supplements · 2021
Astaxanthin (AST), a naturally-occurring keto-carotenoid found in several species of bacteria and microalgae, has demonstrated diverse biological activities
PubMed PMID: 32202443
[11] A Review of the Use of Biotin for Hair Loss.
Patel DP, Swink SM, Castelo-Soccio L · Skin appendage disorders · 2017
Biotin has gained commercial popularity for its claimed benefits on healthy hair and nail growth. Despite its reputation, there is limited research to support the utility of biotin in healthy individu...
PubMed PMID: 28879195
[12] The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomi...
Patel MN, Maheshvari J, Patel N · Cureus · 2025
Background Biotin, a vital cofactor for carboxylase enzymes, plays a key role in metabolic processes, while silica is believed to support collagen synthesis, contributing to improved skin and hair hea...
PubMed PMID: 40896024
V-DAILY — Complete Daily Multivitamin (10 citations)
[1] Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and ...
Vyas CM, Manson JE, Sesso HD et al. · The American journal of clinical nutrition · 2024
Longer effects of multivitamin-mineral (MVM) supplementation on late-life cognitive function remain untested using in-person, detailed neuropsychological assessments. Furthermore, insufficient evidenc...
PubMed PMID: 38244989
[2] Potential mental and physical benefits of supplementation with a high-dose, B-complex multivitamin/mineral supplement: What is the evidence?
Sarris J, Mehta B, Óvári V et al. · Nutricion hospitalaria · 2021
Objective: to perform a systematic literature review to examine the effects of high-dose, B-complex multivitamin/mineral supplementation on physical, mental, and energy outcomes in healthy and 'at-ris...
PubMed PMID: 34530623
[3] Vitamin D and immune function.
Prietl B, Treiber G, Pieber TR et al. · Nutrients · 2013
Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data sho...
PubMed PMID: 23857223
[4] Vitamin D: immune function, inflammation, infections and auto-immunity.
Johnson CR, Thacher TD · Paediatrics and international child health · 2023
Vitamin D plays an active role beyond mineral metabolism and skeletal health, including regulation of the immune system. Vitamin D deficiency is widely prevalent, and observational studies link low vi...
PubMed PMID: 36857810
[5] Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence.
Tardy AL, Pouteau E, Marquez D et al. · Nutrients · 2020
Vitamins and minerals are essential to humans as they play essential roles in a variety of basic metabolic pathways that support fundamental cellular functions. In particular, their involvement in ene...
PubMed PMID: 31963141
[6] A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a rando...
Lee MC, Hsu YJ, Shen SY et al. · International journal of medical sciences · 2023
B vitamins play a crucial role in maintaining fundamental cellular functions and various essential metabolic pathways in the body. Although they do not directly provide energy, each B vitamin acts as ...
PubMed PMID: 37786445
[7] A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection.
Gombart AF, Pierre A, Maggini S · Nutrients · 2020
Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system ne...
PubMed PMID: 31963293
[8] The Role of Zinc in Antiviral Immunity.
Read SA, Obeid S, Ahlenstiel C et al. · Advances in nutrition (Bethesda, Md.) · 2019
Zinc is an essential trace element that is crucial for growth, development, and the maintenance of immune function. Its influence reaches all organs and cell types, representing an integral component ...
PubMed PMID: 31305906
[9] Magnesium and Migraine.
Dominguez LJ, Veronese N, Sabico S et al. · Nutrients · 2025
Migraine is a widespread and intricate neurological condition that involves various factors and is marked by recurring headache episodes. Migraine is among the ten neurological conditions accounting f...
PubMed PMID: 40005053
[10] The effect of magnesium supplementation on muscle fitness: a meta-analysis and systematic review.
Wang R, Chen C, Liu W et al. · Magnesium research · 2017
Increasing evidence supports a role of magnesium (Mg) in skeletal muscle function. However, no systematic review or meta-analysis has summarized data on Mg supplementation in relation to muscle fitnes...
PubMed PMID: 29637897
V-OMEGA 3 — Omega-3 EPA & DHA (8 citations)
[1] Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits.
Shahidi F, Ambigaipalan P · Annual review of food science and technology · 2018
Omega-3 polyunsaturated fatty acids (PUFAs) include α-linolenic acid (ALA; 18:3 ω-3), stearidonic acid (SDA; 18:4 ω-3), eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), an...
PubMed PMID: 29350557
[2] An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health.
Elagizi A, Lavie CJ, O'Keefe E et al. · Nutrients · 2021
Interest in the potential cardiovascular (CV) benefits of omega-3 polyunsaturated fatty acids (Ω-3) began in the 1940s and was amplified by a subsequent landmark trial showing reduced CV disease (CVD)...
PubMed PMID: 33445534
[3] Effect of Anti-Inflammatory Diets on Pain in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
Schönenberger KA, Schüpfer AC, Gloy VL et al. · Nutrients · 2021
Various nutritional therapies have been proposed in rheumatoid arthritis, particularly diets rich in ω-3 fatty acids, which may lead to eicosanoid reduction. Our aim was to investigate the effect of p...
PubMed PMID: 34959772
[4] Omega-3 Supplementation and Its Effects on Osteoarthritis.
Shawl M, Geetha T, Burnett D et al. · Nutrients · 2024
Osteoarthritis (OA) is a degenerative joint disease characterized by the destruction of the articular cartilage, resulting in a pro-inflammatory response. The progression of OA is multifactorial and i...
PubMed PMID: 38892583
[5] Efficacy of omega-3 PUFAs in depression: A meta-analysis.
Liao Y, Xie B, Zhang H et al. · Translational psychiatry · 2019
We conducted this meta-analysis of double-blind randomized placebo-controlled trials to estimate the efficacy of omega-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA) and ...
PubMed PMID: 31383846
[6] Dietary Supplementations and Depression.
Thurfah JN, Christine, Bagaskhara PP et al. · Journal of multidisciplinary healthcare · 2022
Depression is a mood disturbance condition that occurs for more than two weeks in a row, leading to suicide. Due to adverse effects of depression, antidepressants and adjunctive therapies, such as die...
PubMed PMID: 35607362
[7] Effectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial.
Mozaffarian D, Maki KC, Bays HE et al. · JAMA network open · 2022
Intense interest exists in novel ω-3 formulations with high bioavailability to reduce blood triglyceride (TG) levels.
PubMed PMID: 34989797
[8] Association Between Omega-3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose-Response Meta-Analysis of Randomized Controlled Trials.
Wang T, Zhang X, Zhou N et al. · Journal of the American Heart Association · 2023
Background Previous results provide supportive but not conclusive evidence for the use of omega-3 fatty acids to reduce blood lipids and prevent events of atherosclerotic cardiovascular disease, but t...
PubMed PMID: 37264945
V-ITAREN — Joint & Inflammation Support (10 citations)
[1] Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis.
Yu G, Xiang W, Zhang T et al. · BMC complementary medicine and therapies · 2020
Osteoarthritis (OA) is the commonest form of inflammatory joint disease. Unfortunately, to date, there is no appropriate treatment for OA. Boswellia serrata was considered as a potent anti-inflammator...
PubMed PMID: 32680575
[2] Phytomedicine in Joint Disorders.
Dragos D, Gilca M, Gaman L et al. · Nutrients · 2017
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations ...
PubMed PMID: 28275210
[3] Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis.
Meng Z, Liu J, Zhou N · Archives of orthopaedic and trauma surgery · 2023
Though glucosamine and chondroitin have become common practices for treating knee osteoarthritis, the clinical value of these two drugs in combination are still questionable. To evaluate the efficacy ...
PubMed PMID: 35024906
[4] Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
Clegg DO, Reda DJ, Harris CL et al. · The New England journal of medicine · 2006
Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evalu...
PubMed PMID: 16495392
[5] Efficacy and Safety of Curcumin and
Zeng L, Yang T, Yang K et al. · Frontiers in immunology · 2022
Modern pharmacological research found that the chemical components of
PubMed PMID: 35935936
[6] Turmeric and Curcumin: From Traditional to Modern Medicine.
Akaberi M, Sahebkar A, Emami SA · Advances in experimental medicine and biology · 2021
The rhizome of turmeric (Curcuma longa L.) has been used as an herbal medicine, coloring agent, spice, and food additive for thousands of years in different parts of the world particularly in Asian co...
PubMed PMID: 34331682
[7] Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.
Toguchi A, Noguchi N, Kanno T et al. · Nutrients · 2023
Methylsulfonylmethane (MSM) is a food ingredient present in small amounts in many foods, and its anti-inflammatory effects have been reported. We conducted a randomized, double-blind, placebo-controll...
PubMed PMID: 37447322
[8] Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement.
Butawan M, Benjamin RL, Bloomer RJ · Nutrients · 2017
Methylsulfonylmethane (MSM) has become a popular dietary supplement used for a variety of purposes, including its most common use as an anti-inflammatory agent. It has been well-investigated in animal...
PubMed PMID: 28300758
[9] Palmitoylethanolamide: A Natural Compound for Health Management.
Clayton P, Hill M, Bogoda N et al. · International journal of molecular sciences · 2021
All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stre...
PubMed PMID: 34069940
[10] Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer.
Cicero AFG, Allkanjari O, Busetto GM et al. · Archivio italiano di urologia, andrologia : organo uffici... · 2019
During the last years, pharmaceutical innovations in primary care are dramatically less frequent and will be even more rare in the next future. In this context, preclinical and clinical research orien...
PubMed PMID: 31577095
V-ORGANEX — Liver Detox & Gut Health (9 citations)
[1] Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review.
Soleimani V, Delghandi PS, Moallem SA et al. · Phytotherapy research : PTR · 2019
Milk thistle (Silybum marianum) is a medicinal plant from the Asteraceae family. Silymarin is the major constituent of milk thistle extract and is a mixture of some flavonolignans such as silybin, whi...
PubMed PMID: 31069872
[2] Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer.
Fallah M, Davoodvandi A, Nikmanzar S et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacothe... · 2021
Silymarin contains a group of closely-related flavonolignan compounds including silibinin, and is extracted from Silybum marianum species, also called milk thistle. Silymarin has been shown to protect...
PubMed PMID: 34399200
[3] Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions.
Yan M, Huo Y, Yin S et al. · Redox biology · 2018
Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in many developed countries. Mitochondrial oxidative stress is considered to be the predominant cellular event in...
PubMed PMID: 29753208
[4] Clinical applications of N-acetylcysteine.
Kelly GS · Alternative medicine review : a journal of clinical thera... · 1998
N-acetylcysteine (NAC), the acetylated variant of the amino acid L-cysteine, is an excellent source of sulfhydryl (SH) groups, and is converted in the body into metabolites capable of stimulating glut...
PubMed PMID: 9577247
[5] Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease.
Ignat MV, Coldea TE, Salanță LC et al. · Plants (Basel, Switzerland) · 2021
The current pharmacological agents advised for the management of diabetes as well as cardiovascular and hepatic diseases are subject to numerous studies for safety and efficacy. Therefore, it is worth...
PubMed PMID: 33498684
[6] Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial.
Panahi Y, Kianpour P, Mohtashami R et al. · Phytotherapy research : PTR · 2018
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and is potentially treatable, though there are few therapeutic agents available. Artichoke leaf ex...
PubMed PMID: 29520889
[7] Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Ben Salem M, Affes H, Ksouda K et al. · Plant foods for human nutrition (Dordrecht, Netherlands) · 2015
Artichoke (Cynara scolymus) leaf extract was one of the few herbal remedies which the clinical and experimental trials have complemented each other. Both experimental and clinical effects have been ve...
PubMed PMID: 26310198
[8] α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte.
Zhao Y, Guo M, Pei T et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Liver disease poses a significant threat to global public health, with arsenic (As) recognized as a major environmental toxin contributing to liver injury. However, the specific mechanisms and the pro...
PubMed PMID: 39887668
[9] Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy.
Zhang T, Zhang D, Zhang Z et al. · Hormones (Athens, Greece) · 2023
To investigate the AMPK pathway-mediated effect of alpha-lipoic acid (ALA) on the dorsal root ganglia (DRGs) of rats with diabetic peripheral neuropathy (DPN) and to attempt to elucidate the underlyin...
PubMed PMID: 36289188
V-CURCUMAX — Curcumin & Piperine Complex (10 citations)
[1] Bioavailability of curcumin: problems and promises.
Anand P, Kunnumakkara AB, Newman RA et al. · Molecular pharmaceutics · 2007
Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities...
PubMed PMID: 17999464
[2] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
Shoba G, Joy D, Joseph T et al. · Planta medica · 1998
The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In this study, the ...
PubMed PMID: 9619120
[3] Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway.
Zusso M, Lunardi V, Franceschini D et al. · Journal of neuroinflammation · 2019
Neuroinflammation is the response of the central nervous system to events that interfere with tissue homeostasis and represents a common denominator in virtually all neurological diseases. Activation ...
PubMed PMID: 31319868
[4] Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124/NF-kB and miR-143/ROCK1/TLR9 signalling pathways.
Qiu B, Xu X, Yi P et al. · Journal of cellular and molecular medicine · 2020
Curcumin treatment was reported to delay the progression of OA, but its underlying mechanism remains unclear. In this study, we aimed to investigate the molecular mechanism underlying the role of curc...
PubMed PMID: 32776418
[5] Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Cli...
Daily JW, Yang M, Park S · Journal of medicinal food · 2016
Although turmeric and its curcumin-enriched extracts have been used for treating arthritis, no systematic review and meta-analysis of randomized clinical trials (RCTs) have been conducted to evaluate ...
PubMed PMID: 27533649
[6] Efficacy and Safety of Curcumin and
Zeng L, Yang T, Yang K et al. · Frontiers in immunology · 2022
Modern pharmacological research found that the chemical components of
PubMed PMID: 35935936
[7] Antioxidant and anti-inflammatory properties of curcumin.
Menon VP, Sudheer AR · Advances in experimental medicine and biology · 2007
Curcumin, a yellow pigment from Curcuma longa, is a major component of turmeric and is commonly used as a spice and food-coloring agent. It is also used as a cosmetic and in some medical preparations....
PubMed PMID: 17569207
[8] Curcumin, an active component of turmeric (Curcuma longa), and its effects on health.
Kocaadam B, Şanlier N · Critical reviews in food science and nutrition · 2017
Turmeric (Curcuma longa) is a type of herb belonging to ginger family, which is widely grown in southern and south western tropical Asia region. Turmeric, which has an importance place in the cuisines...
PubMed PMID: 26528921
[9] Supplement and nutraceutical therapy in traumatic brain injury.
Lucke-Wold B, Zasler ND, Ruchika F et al. · Nutritional neuroscience · 2025
Traumatic brain injury (TBI) continues to be a leading cause of morbidity and mortality. Nutraceuticals and supplements have emerged as potential therapeutics to enhance brain recovery post-injury.
PubMed PMID: 40440029
[10] Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?
Mazzanti G, Di Giacomo S · Molecules (Basel, Switzerland) · 2016
A growing body of in vitro and in vivo evidences shows a possible role of polyphenols in counteracting neurodegeneration: curcumin and resveratrol are attractive substances in this regard. In fact, ep...
PubMed PMID: 27649135
V-NEUROKAFE — Nootropic Coffee Blend (7 citations)
[1] The combined effects of L-theanine and caffeine on cognitive performance and mood.
Owen GN, Parnell H, De Bruin EA et al. · Nutritional neuroscience · 2008
The aim of this study was to compare 50 mg caffeine, with and without 100 mg L-theanine, on cognition and mood in healthy volunteers. The effects of these treatments on word recognition, rapid visual ...
PubMed PMID: 18681988
[2] The effects of L-theanine, caffeine and their combination on cognition and mood.
Haskell CF, Kennedy DO, Milne AL et al. · Biological psychology · 2008
L-Theanine is an amino acid found naturally in tea. Despite the common consumption of L-theanine, predominantly in combination with caffeine in the form of tea, only one study to date has examined the...
PubMed PMID: 18006208
[3] Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance.
La Monica MB, Raub B, Ziegenfuss EJ et al. · Nutrients · 2023
The aim of this study was to assess the effects of guayusa extract and Nordic Lion's Mane (LM) on cognition. Using a randomized, double-blind, placebo-controlled, crossover design, we examined the eff...
PubMed PMID: 38140277
[4] The Safety and Efficacy of Botanicals with Nootropic Effects.
Roe AL, Venkataraman A · Current neuropharmacology · 2021
Recent estimates for the global brain health supplement category, i.e. nootropic market size, will grow to nearly $5.8 billion by 2023. Overall, nearly one-quarter (23%) of adults currently take a sup...
PubMed PMID: 34315377
[5] A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: R...
Majeed M, Nagabhushanam K, Mundkur L · Medicine · 2023
The coronavirus disease-2019 (COVID-19) pandemic has resulted in a surge in stress, anxiety, and depression worldwide. Ashwagandha, an ayurvedic adaptogen has been traditionally used to manage stress,...
PubMed PMID: 37832082
[6] Effects of
Pandit S, Srivastav AK, Sur TK et al. · Nutrients · 2024
Stress is a known causative factor in modulating cognitive health, which overall well-being and quality of life are dependent on. Long-term stress has been shown to disrupt the balance of the hypothal...
PubMed PMID: 38732539
[7] Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, pla...
Calabrese C, Gregory WL, Leo M et al. · Journal of alternative and complementary medicine (New Yo... · 2008
Study aims were to evaluate effects of Bacopa monnieri whole plant standardized dry extract on cognitive function and affect and its safety and tolerability in healthy elderly study participants.
PubMed PMID: 18611150
V-NITRO — Nitric Oxide & Circulation (10 citations)
[1] Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease.
Clemons GA, Silva ACE, Acosta CH et al. · Journal of cellular physiology · 2024
Alzheimer's disease (AD) is the leading cause of mortality, disability, and long-term care burden in the United States, with women comprising the majority of AD diagnoses. While AD-related dementia is...
PubMed PMID: 36036549
[2] Role of cellular L-arginine uptake and nitric oxide production on renal blood flow and arterial pressure regulation.
Rajapakse NW, Mattson DL · Current opinion in nephrology and hypertension · 2013
L-Arginine (L-Arg) is the substrate for nitric oxide (NO) formation. Reduced NO bioavailability, particularly within the renal circulation, has been identified as a key factor in the pathogenesis of h...
PubMed PMID: 23095292
[3] Supplementation with Nitric Oxide Precursors for Strength Performance: A Review of the Current Literature.
Gonzalez AM, Townsend JR, Pinzone AG et al. · Nutrients · 2023
Nitric-oxide-stimulating dietary supplements are widely available and marketed to strength athletes and weightlifters seeking to increase muscle performance and augment training adaptations. These sup...
PubMed PMID: 36771366
[4] Effects of Citrulline Supplementation on Exercise Performance in Humans: A Review of the Current Literature.
Gonzalez AM, Trexler ET · Journal of strength and conditioning research · 2020
Gonzalez, AM and Trexler, ET. Effects of citrulline supplementation on exercise performance in humans: A review of the current literature. J Strength Cond Res 34(5): 1480-1495, 2020-L-citrulline, a no...
PubMed PMID: 31977835
[5] Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance.
Jones AM, Vanhatalo A, Seals DR et al. · Medicine and science in sports and exercise · 2021
Nitric oxide (NO) is a gaseous signaling molecule that plays an important role in myriad physiological processes, including the regulation of vascular tone, neurotransmission, mitochondrial respiratio...
PubMed PMID: 32735111
[6] The benefits and risks of beetroot juice consumption: a systematic review.
Zamani H, de Joode MEJR, Hossein IJ et al. · Critical reviews in food science and nutrition · 2021
Beetroot juice (BRJ) has become increasingly popular amongst athletes aiming to improve sport performances. BRJ contains high concentrations of nitrate, which can be converted into nitric oxide (NO) a...
PubMed PMID: 32292042
[7] Nitric oxide synthases: regulation and function.
Förstermann U, Sessa WC · European heart journal · 2012
Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 1.14.13.39). They all utilize l-arginine and molecular oxygen as substrates and require...
PubMed PMID: 21890489
[8] Alterations in endothelial nitric oxide synthase activity and their relevance to blood pressure.
Suvorava T, Metry S, Pick S et al. · Biochemical pharmacology · 2022
Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation of vascular tone is one of the most important. Under physiological conditions vascular NO is mainly generated...
PubMed PMID: 36185001
[9] International society of sports nutrition position stand: caffeine and exercise performance.
Guest NS, VanDusseldorp TA, Nelson MT et al. · Journal of the International Society of Sports Nutrition · 2021
Following critical evaluation of the available literature to date, The International Society of Sports Nutrition (ISSN) position regarding caffeine intake is as follows: 1. Supplementation with caffei...
PubMed PMID: 33388079
[10] The effect of acute pre-workout supplementation on power and strength performance.
Martinez N, Campbell B, Franek M et al. · Journal of the International Society of Sports Nutrition · 2016
Consumption of pre-workout dietary supplements by both recreational and competitive athletes has increased dramatically in recent years. The purpose of this study was to determine the acute effects of...
PubMed PMID: 27429596
V-GLUTATION — Reduced Glutathione (7 citations)
[1] Randomized controlled trial of oral glutathione supplementation on body stores of glutathione.
Richie JP, Nichenametla S, Neidig W et al. · European journal of nutrition · 2015
Glutathione (GSH), the most abundant endogenous antioxidant, is a critical regulator of oxidative stress and immune function. While oral GSH has been shown to be bioavailable in laboratory animal mode...
PubMed PMID: 24791752
[2] An Open-Label Case Series of Glutathione Use for Symptomatic Management in Children with Autism Spectrum Disorder.
Radwan K, Wu G, Banks-Word K et al. · Medical sciences (Basel, Switzerland) · 2023
Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that has been diagnosed in an increasing number of children around the world. The existing data suggest that early diagnosis and...
PubMed PMID: 37987328
[3] The antioxidant glutathione.
Averill-Bates DA · Vitamins and hormones · 2023
Reduced glutathione (GSH) is an essential non-enzymatic antioxidant in mammalian cells. GSH can act directly as an antioxidant to protect cells against free radicals and pro-oxidants, and as a cofacto...
PubMed PMID: 36707132
[4] Antioxidant Protection of NADPH-Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione.
Kilanczyk E, Saraswat Ohri S, Whittemore SR et al. · ASN neuro · 2016
The pentose phosphate pathway is the main source of NADPH, which by reducing oxidized glutathione, contributes to antioxidant defenses. Although oxidative stress plays a major role in white matter inj...
PubMed PMID: 27449129
[5] Glutathione metabolism in cancer progression and treatment resistance.
Bansal A, Simon MC · The Journal of cell biology · 2018
Glutathione (GSH) is the most abundant antioxidant found in living organisms and has multiple functions, most of which maintain cellular redox homeostasis. GSH preserves sufficient levels of cysteine ...
PubMed PMID: 29915025
[6] DCAF1 regulates Treg senescence via the ROS axis during immunological aging.
Guo Z, Wang G, Wu B et al. · The Journal of clinical investigation · 2020
As a hallmark of immunological aging, low-grade, chronic inflammation with accumulation of effector memory T cells contributes to increased susceptibility to many aging-related diseases. While the pro...
PubMed PMID: 32730228
[7] Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity.
Zhou L, Lian G, Zhou T et al. · Nature cancer · 2025
Ferroptosis is closely linked with various pathophysiological processes, including aging, neurodegeneration, ischemia-reperfusion injury, viral infection and, notably, cancer progression; however, its...
PubMed PMID: 40108413
V-ITALAY — Sleep & Stress Relief (10 citations)
[1] An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, ...
Lopresti AL, Smith SJ, Malvi H et al. · Medicine · 2019
Ashwagandha (Withania somnifera (L.) Dunal) is a herb traditionally used to reduce stress and enhance wellbeing. The aim of this study was to investigate its anxiolytic effects on adults with self-rep...
PubMed PMID: 31517876
[2] A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandh...
Chandrasekhar K, Kapoor J, Anishetty S · Indian journal of psychological medicine · 2012
Stress is a state of mental or emotional strain or tension, which can lead to underperformance and adverse clinical conditions. Adaptogens are herbs that help in combating stress. Ayurvedic classical ...
PubMed PMID: 23439798
[3] Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
Shinjyo N, Waddell G, Green J · Journal of evidence-based integrative medicine · 2020
Sleep problems are widely prevalent and associated with various comorbidities including anxiety. Valerian (
PubMed PMID: 33086877
[4] Nutritional Supplements for Healthy Aging: A Critical Analysis Review.
Kaufman MW, DeParis S, Oppezzo M et al. · American journal of lifestyle medicine · 2025
PubMed PMID: 39554957
[5] The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature.
Arab A, Rafie N, Amani R et al. · Biological trace element research · 2023
To date, no study has critically reviewed the current literature on the association between magnesium (Mg) and sleep health. Therefore, we carried out a systematic review to assess the association bet...
PubMed PMID: 35184264
[6] Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
Hausenblas HA, Lynch T, Hooper S et al. · Sleep medicine: X · 2024
Sleep problems challenge overall wellbeing. Magnesium has been implicated to benefit sleep, although the clinical evidences varied based on the magnesium source used. Magnesium L-threonate (MgT) is a ...
PubMed PMID: 39252819
[7] A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality.
Ngan A, Conduit R · Phytotherapy research : PTR · 2011
Passiflora incarnata is a traditional herbal sedative, anxiolytic and a popular sleep aid used for the treatment of sleep disturbance. Several controlled experiments have demonstrated enhanced sleep i...
PubMed PMID: 21294203
[8] Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.
Borrás S, Martínez-Solís I, Ríos JL · Planta medica · 2021
Sleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are differen...
PubMed PMID: 34116572
[9] An Integrative Approach to HPA Axis Dysfunction: From Recognition to Recovery.
Ring M · The American journal of medicine · 2025
The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in the body's stress response and is increasingly recognized as a contributor to a range of chronic health conditions. This review ai...
PubMed PMID: 40499704
[10] Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic-pituitary-adrenal (HPA) axis in modulating stress.
C M MG, Murugan SK, Bethapudi B et al. · PloS one · 2023
Ocimum tenuiflorum is a sacred medicinal plant bestowed with multiple health benefits. This plant is traditionally considered an adaptogen. Many scientific studies have indicated the anti-stress poten...
PubMed PMID: 37141281
V-CONTROL — Blood Sugar & Metabolic Support (10 citations)
[1] Efficacy of berberine in patients with type 2 diabetes mellitus.
Yin J, Xing H, Ye J · Metabolism: clinical and experimental · 2008
Berberine has been shown to regulate glucose and lipid metabolism in vitro and in vivo. This pilot study was to determine the efficacy and safety of berberine in the treatment of type 2 diabetes melli...
PubMed PMID: 18442638
[2] Berberine and health outcomes: An umbrella review.
Li Z, Wang Y, Xu Q et al. · Phytotherapy research : PTR · 2023
Berberine is a plant extract widely used in clinical practice. This review aimed to summarize and to grade the available evidence on the association between berberine consumption and health-related ou...
PubMed PMID: 36999891
[3] Chromium supplementation and type 2 diabetes mellitus: an extensive systematic review.
Georgaki MN, Tsokkou S, Keramas A et al. · Environmental geochemistry and health · 2024
Diabetes is a global public health concern with increasing prevalence worldwide. Chromium (Cr), a trace element found in soil, water, and food, has been proposed to have a possible positive effect in ...
PubMed PMID: 39541030
[4] A scientific review: the role of chromium in insulin resistance.
Havel PJ · The Diabetes educator · 2004
Chromium is an essential mineral that appears to have a beneficial role in the regulation of insulin action and its effects on carbohydrate, protein and lipid metabolism. Chromium is an important fact...
PubMed PMID: 15208835
[5] Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism o...
Silva ML, Bernardo MA, Singh J et al. · Nutrients · 2022
The scientific evidence that cinnamon may exert beneficial effects on type 2 diabetes mellitus due to the biological activity of its bioactive compounds has been increasing in recent years. This revie...
PubMed PMID: 35807953
[6] Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, c...
Muthukuda D, de Silva CK, Ajanthan S et al. · PloS one · 2025
Cinnamon has been studied as a possible way to control blood glucose and serum cholesterol levels. However, there are no well-conducted randomized controlled trials that can accurately measure the lip...
PubMed PMID: 39854533
[7] Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features.
Capece U, Moffa S, Improta I et al. · Nutrients · 2022
Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely prescribed in ...
PubMed PMID: 36615676
[8] Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome.
Alesi S, Ee C, Moran LJ et al. · Advances in nutrition (Bethesda, Md.) · 2022
Polycystic ovary syndrome (PCOS) affects 1 in 5 women of reproductive age, and is characterized by menstrual irregularities, clinical or biochemical hyperandrogenism, and the presence of polycystic ov...
PubMed PMID: 34970669
[9] The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis.
Devangan S, Varghese B, Johny E et al. · Phytotherapy research : PTR · 2021
This systematic review and meta-analysis aims to find the effect of Gymnema sylvestre (GS) supplementation on glycemic control in type-2 diabetes mellitus (T2DM). PubMed, Cochrane library, Google Scho...
PubMed PMID: 34467577
[10] The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A system...
Zamani M, Ashtary-Larky D, Nosratabadi S et al. · Phytotherapy research : PTR · 2023
There is a growing interest in the considerable health benefits of Gymnema Sylvestre (GS) supplementation, as some studies have reported that it may improve cardiometabolic risk factors. However, the ...
PubMed PMID: 36580574
V-ASCULAX — Cardiovascular & Vascular Health (8 citations)
[1] Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency.
Rehn D, Unkauf M, Klein P et al. · Arzneimittel-Forschung · 1996
Oxerutins (O-(beta-hydroxyethyl)rutosides, HR, Venoruton) and horse chestnut extract (HCE) are active principles of first priority for the pharmacological treatment of chronic venous insufficiency (CV...
PubMed PMID: 8737631
[2] A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic opti...
Wollina U, Abdel-Naser MB, Mani R · The international journal of lower extremity wounds · 2006
Impairment of the cutaneous microcirculation is a major predisposing factor in inflammation and ulceration in patients with chronic venous insufficiency (CVI). Increase of capillary filtration rate pr...
PubMed PMID: 16928673
[3] Neuroprotective effects of Ginkgo biloba extract.
Ahlemeyer B, Krieglstein J · Cellular and molecular life sciences : CMLS · 2003
Ginkgo biloba extract has been therapeutically used for several decades to increase peripheral and cerebral blood flow as well as for the treatment of dementia. The extract contains multiple compounds...
PubMed PMID: 14523543
[4] Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications.
McKenna DJ, Jones K, Hughes K · Alternative therapies in health and medicine · 2001
Ginkgo biloba is a dioecious tree with a history of use in traditional Chinese medicine. Although the seeds are most commonly employed in traditional Chinese medicine, in recent years standardized ext...
PubMed PMID: 11565403
[5] Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Li X, Long J, Gao Q et al. · Reviews in cardiovascular medicine · 2023
As a fibrinolytic enzyme from fermented soybean, nattokinase has been shown to be potentially beneficial for cardiovascular health, but current clinical evidences regarding the nattokinase supplementa...
PubMed PMID: 39076715
[6] Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease.
Weng Y, Yao J, Sparks S et al. · International journal of molecular sciences · 2017
Natto, a fermented soybean product, has been consumed as a traditional food in Japan for thousands of years. Nattokinase (NK), a potent blood-clot dissolving protein used for the treatment of cardiova...
PubMed PMID: 28264497
[7] MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options.
El-Hattab AW, Adesina AM, Jones J et al. · Molecular genetics and metabolism · 2015
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is one of the most frequent maternally inherited mitochondrial disorders. MELAS syndrome is a multi-organ di...
PubMed PMID: 26095523
[8] Effects of statins on mitochondrial pathways.
Mollazadeh H, Tavana E, Fanni G et al. · Journal of cachexia, sarcopenia and muscle · 2021
Statins are a family of drugs that are used for treating hyperlipidaemia with a recognized capacity to prevent cardiovascular disease events. They inhibit β-hydroxy β-methylglutaryl-coenzyme A reducta...
PubMed PMID: 33511728
V-ITADOL — Natural Pain Relief (9 citations)
[1] Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study.
Chrubasik S, Eisenberg E, Balan E et al. · The American journal of medicine · 2000
Herbal medicines are widely used for the treatment of pain, although there is not much information on their effectiveness. This study was designed to evaluate the effectiveness of willow (Salix) bark ...
PubMed PMID: 10936472
[2] The Fight against Infection and Pain: Devil's Claw (
Gxaba N, Manganyi MC · Molecules (Basel, Switzerland) · 2022
PubMed PMID: 35684573
[3] Devil's Claw-a review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens.
Mncwangi N, Chen W, Vermaak I et al. · Journal of ethnopharmacology · 2012
Harpagophytum procumbens subps. procumbens (Burch.) DC. ex Meisn. (Pedaliaceae) is an important traditional medicine growing in the Kalahari region of southern Africa where it is consumed as a general...
PubMed PMID: 22940241
[4] Nutritional Supplements in the Clinical Management of Tendinopathy: A Scoping Review.
Burton I, McCormack A · Journal of sport rehabilitation · 2023
Tendinopathy has a high prevalence and incidence in the general population and among athletes, with a lack of consensus among medical practitioners on optimal management strategies. The objective of t...
PubMed PMID: 37146985
[5] An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinic...
Colletti A, Procchio C, Pisano M et al. · Nutrients · 2024
A three-arm, randomized, placebo-controlled clinical study was conducted to assess the impact of lyophilized pineapple extract with titrated bromelain (Brome-Inf
PubMed PMID: 38542694
[6] Phytomedicine in Joint Disorders.
Dragos D, Gilca M, Gaman L et al. · Nutrients · 2017
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations ...
PubMed PMID: 28275210
[7] Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degeneration: A Randomized, Doub...
Vaidya N, Agarwal R, Dipankar DG et al. · Pharmaceutical research · 2025
Osteoarthritis is the prevailing form of inflammatory condition in joints of adults and the aging population, leading to long-term disability and chronic pain. Current therapeutic options have variabl...
PubMed PMID: 39875757
[8] A 2022 Systematic Review and Meta-Analysis of Enriched Therapeutic Diets and Nutraceuticals in Canine and Feline Osteoarthritis.
Barbeau-Grégoire M, Otis C, Cournoyer A et al. · International journal of molecular sciences · 2022
With osteoarthritis being the most common degenerative disease in pet animals, a very broad panel of natural health products is available on the market for its management. The aim of this systematic r...
PubMed PMID: 36142319
[9] Palmitoylethanolamide: A Natural Compound for Health Management.
Clayton P, Hill M, Bogoda N et al. · International journal of molecular sciences · 2021
All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stre...
PubMed PMID: 34069940
V-ITALBOOST — Immune System Booster (8 citations)
[1] Vitamin C and Immune Function.
Carr AC, Maggini S · Nutrients · 2017
Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic and ge...
PubMed PMID: 29099763
[2] Immune-enhancing role of vitamin C and zinc and effect on clinical conditions.
Wintergerst ES, Maggini S, Hornig DH · Annals of nutrition & metabolism · 2006
Vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress. Supplementation of vitamin C was found to improve components of the human immune system such as anti...
PubMed PMID: 16373990
[3] ESPEN micronutrient guideline.
Berger MM, Shenkin A, Schweinlin A et al. · Clinical nutrition (Edinburgh, Scotland) · 2022
Trace elements and vitamins, named together micronutrients (MNs), are essential for human metabolism. Recent research has shown the importance of MNs in common pathologies, with significant deficienci...
PubMed PMID: 35365361
[4] Nutrition and Atopic Dermatitis.
Kanda N, Hoashi T, Saeki H · Journal of Nippon Medical School = Nippon Ika Daigaku zasshi · 2021
Atopic dermatitis (AD) is a chronic eczematous disease characterized by T helper 2 (Th2) -shifted allergic immunity, skin barrier impairment, and pruritus. Oral intake of certain nutrients might help ...
PubMed PMID: 33692290
[5] Ayurvedic and Chinese Herbs against Coronaviruses.
Gasmi A, Kanwal S, Oliinyk P et al. · Current pharmaceutical design · 2024
Coronavirus disease 2019 (COVID-19) is a viral disease that infects the lower airways, causing severe acute respiratory syndrome (SARS) and fatal pneumonia. The ripple effect of the COVID-19 outbreak ...
PubMed PMID: 38685809
[6] Antiviral effects of flavonoids on animal viruses.
da Fonseca RN, Maggioli MF, de Oliveira Hübner S et al. · Virology · 2025
Flavonoids, plant-derived compounds widely recognized for their antioxidant, anti-inflammatory, and anticancer properties, also exhibit significant antiviral effects against various animal viruses. Th...
PubMed PMID: 40527067
[7] Clinical benefits of β-glucan supplementation in children: a review.
Bhoite R, Satyavrat V, Premasudha Sadananda M · Discover food · 2022
Malnutrition is a global concern since it affects 130 million children under the age of 5 worldwide. The child's immunity is brutally compromised, making them susceptible to various diseases and infec...
PubMed PMID: 40477820
[8] In-vivo analysis of Protec™ and β-glucan supplementation on innate immune performance and intestinal health of rainbow trout.
Porter D, Peggs D, McGurk C et al. · Fish & shellfish immunology · 2023
Functional diets are often given to fish during key stages to improve health through the interaction of the feed components with the host intestine. The additional factors added in these diets are kno...
PubMed PMID: 36720374
V-FORTYFLORA — Probiotic for Adults 40+ (10 citations)
[1] Gut Microbiota-Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice.
Lee J, d'Aigle J, Atadja L et al. · Circulation research · 2020
The elderly experience profound systemic responses after stroke, which contribute to higher mortality and more severe long-term disability. Recent studies have revealed that stroke outcomes can be inf...
PubMed PMID: 32354259
[2] Understanding the gut microbiota and sarcopenia: a systematic review.
Liu C, Cheung WH, Li J et al. · Journal of cachexia, sarcopenia and muscle · 2021
Gut microbiota dysbiosis and sarcopenia commonly occur in the elderly. Although the concept of the gut-muscle axis has been raised, the casual relationship is still unclear. This systematic review ana...
PubMed PMID: 34523250
[3] The study evaluating the effect of probiotic supplementation on the mental status, inflammation, and intestinal barrier in major depressive disorde...
Karakula-Juchnowicz H, Rog J, Juchnowicz D et al. · Nutrition journal · 2019
Current treatment of major depressive disorder (MDD) often does not achieve full remission of symptoms. Therefore, new forms of treatment and/or adjunct therapy are needed. Evidence has confirmed the ...
PubMed PMID: 31472678
[4] Short-term probiotic supplementation enhances cellular immune function in healthy elderly: systematic review and meta-analysis of controlled studies.
Miller LE, Lehtoranta L, Lehtinen MJ · Nutrition research (New York, N.Y.) · 2019
Immune function declines with advancing age. Probiotic supplementation has been proposed to slow or reverse these age-related changes. The primary objective of this study was to evaluate the effect of...
PubMed PMID: 30802719
[5] The Microbiota-Gut-Brain Axis.
Cryan JF, O'Riordan KJ, Cowan CSM et al. · Physiological reviews · 2019
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and...
PubMed PMID: 31460832
[6] Gut microbiota and aging.
Ling Z, Liu X, Cheng Y et al. · Critical reviews in food science and nutrition · 2022
Aging is characterized by the functional decline of tissues and organs and increased risk of aging-associated disorders, which pose major societal challenges and are a public health priority. Despite ...
PubMed PMID: 33377391
[7] Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.
Goodoory VC, Khasawneh M, Black CJ et al. · Gastroenterology · 2023
Some probiotics may be beneficial in irritable bowel syndrome (IBS), but differences in species and strains used, as well as endpoints reported, have hampered attempts to make specific recommendations...
PubMed PMID: 37541528
[8] A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live
Srivastava S, Basak U, Naghibi M et al. · Gut microbes · 2024
To determine the efficacy of the probiotic
PubMed PMID: 38630015
[9] Probiotic, prebiotic, synbiotic and fermented food supplementation in psychiatric disorders: A systematic review of clinical trials.
Ribera C, Sánchez-Ortí JV, Clarke G et al. · Neuroscience and biobehavioral reviews · 2024
The use of probiotics, prebiotics, synbiotics or fermented foods can modulate the gut-brain axis and constitute a potentially therapeutic intervention in psychiatric disorders. This systematic review ...
PubMed PMID: 38280441
[10] Gut microbiome-targeted therapies for Alzheimer's disease.
Zhang T, Gao G, Kwok LY et al. · Gut microbes · 2023
The advent of high-throughput 'omics' technologies has improved our knowledge of gut microbiome in human health and disease, including Alzheimer's disease (AD), a neurodegenerative disorder. Frequent ...
PubMed PMID: 37934614
VITALPRO — Premium Protein & Amino Acids (10 citations)
[1] Whey Protein, Leucine- and Vitamin-D-Enriched Oral Nutritional Supplementation for the Treatment of Sarcopenia.
Cereda E, Pisati R, Rondanelli M et al. · Nutrients · 2022
Sarcopenia has been recognized as a muscle disease, with adverse consequences on health. Updated recommendations, aimed at increasing awareness of sarcopenia and its accompanying risks, have been prod...
PubMed PMID: 35406137
[2] Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Meta-Analysis.
Chang MC, Choo YJ · Nutrients · 2023
(1) Background: In this study, a meta-analysis was performed to investigate the effects of whey protein, leucine, and vitamin D in sarcopenia; (2) Methods: We searched PubMed, Cochrane Library, Embase...
PubMed PMID: 36771225
[3] Effectiveness of Whey Protein Supplementation during Resistance Exercise Training on Skeletal Muscle Mass and Strength in Older People with Sarcope...
Cuyul-Vásquez I, Pezo-Navarrete J, Vargas-Arriagada C et al. · Nutrients · 2023
To determine the effectiveness of whey protein (WP) supplementation during resistance exercise training (RET) vs. RET with or without placebo supplementation on skeletal muscle mass, strength, and phy...
PubMed PMID: 37571361
[4] Supplemental protein in support of muscle mass and health: advantage whey.
Devries MC, Phillips SM · Journal of food science · 2015
Skeletal muscle is an integral body tissue playing key roles in strength, performance, physical function, and metabolic regulation. It is essential for athletes to ensure that they have optimal amount...
PubMed PMID: 25757896
[5] Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review.
Martinho DV, Nobari H, Faria A et al. · Nutrients · 2022
Branched-chain amino acids (BCAAs) are oxidized in the muscle and result in stimulating anabolic signals-which in return may optimize performance, body composition and recovery. Meanwhile, among athle...
PubMed PMID: 36235655
[6] Branched-Chain Amino Acids Supplementation and Post-Exercise Recovery: An Overview of Systematic Reviews.
Salem A, Trabelsi K, Jahrami H et al. · Journal of the American Nutrition Association · 2024
PubMed PMID: 38241335
[7] Values for digestible indispensable amino acid scores (DIAAS) for some dairy and plant proteins may better describe protein quality than values cal...
Mathai JK, Liu Y, Stein HH · The British journal of nutrition · 2017
An experiment was conducted to compare values for digestible indispensable amino acid scores (DIAAS) for four animal proteins and four plant proteins with values calculated as recommended for protein ...
PubMed PMID: 28382889
[8] Protein quality malnutrition.
Manary MJ, Wegner DR, Maleta K · Frontiers in nutrition · 2024
Protein quality refers to the evaluation of a food or a diet based on its amino acid composition, protein digestibility, and protein bioavailability. When these parameters are specified, either throug...
PubMed PMID: 39507895
[9] Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape.
O'Malley RC, Huang SC, Song L et al. · Cell · 2016
The cistrome is the complete set of transcription factor (TF) binding sites (cis-elements) in an organism, while an epicistrome incorporates tissue-specific DNA chemical modifications and TF-specific ...
PubMed PMID: 27203113
[10] The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family.
Yanhui C, Xiaoyuan Y, Kun H et al. · Plant molecular biology · 2006
MYB proteins are a superfamily of transcription factors that play regulatory roles in developmental processes and defense responses in plants. We identified 198 genes in the MYB superfamily from an an...
PubMed PMID: 16463103
V-NRGY — Natural Energy & Vitality (8 citations)
[1] The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.
Hijjawi N, Tout FS, Azaizeh B et al. · Clinical rheumatology · 2025
Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by joint inflammation and destruction. Recent studies emphasize the importance of vitamins D, B12, C, and K in managing RA and enhanci...
PubMed PMID: 39722107
[2] Energetic homeostasis achieved through biophoton energy and accompanying medication treatment resulted in sustained levels of Thyroiditis-Hashimoto...
Smotrys MA, Liu JZ, Street S et al. · Metabolism open · 2023
We present the case of a 37-year-old premenopausal woman, who presented with fatigue, weakness, pallor, and myalgias. She was on treatment for Hashimoto's Thyroiditis, iron deficiency anemia, deficien...
PubMed PMID: 37303826
[3] MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options.
El-Hattab AW, Adesina AM, Jones J et al. · Molecular genetics and metabolism · 2015
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is one of the most frequent maternally inherited mitochondrial disorders. MELAS syndrome is a multi-organ di...
PubMed PMID: 26095523
[4] Mitochondrial regulation of ferroptosis.
Gan B · The Journal of cell biology · 2021
Ferroptosis is a form of iron-dependent regulated cell death driven by uncontrolled lipid peroxidation. Mitochondria are double-membrane organelles that have essential roles in energy production, cell...
PubMed PMID: 34328510
[5] The incidence, complications, and treatment of iron deficiency in pregnancy.
Benson AE, Shatzel JJ, Ryan KS et al. · European journal of haematology · 2022
Iron deficiency and/or iron deficiency anemia (IDA) complicate nearly 50% of pregnancies globally, negatively impacting both maternal and fetal outcomes. Iron deficiency can cause a range of symptoms ...
PubMed PMID: 36153674
[6] The role of iron repletion in adult iron deficiency anemia and other diseases.
Elstrott B, Khan L, Olson S et al. · European journal of haematology · 2020
Iron deficiency anemia (IDA) is the most prevalent and treatable form of anemia worldwide. The clinical management of patients with IDA requires a comprehensive understanding of the many etiologies th...
PubMed PMID: 31715055
[7] A review of caffeine's effects on cognitive, physical and occupational performance.
McLellan TM, Caldwell JA, Lieberman HR · Neuroscience and biobehavioral reviews · 2016
Caffeine is consumed by over 80% of U.S. adults. This review examines the effects caffeine has on cognitive and physical function, since most real-world activities require complex decision making, mot...
PubMed PMID: 27612937
[8] The effects of red bull energy drink on human performance and mood.
Alford C, Cox H, Wescott R · Amino acids · 2001
The effects of Red Bull Energy Drink, which includes taurine, glucuronolactone, and caffeine amongst the ingredients, were examined over 3 studies in a total of 36 volunteers. Assessments included psy...
PubMed PMID: 11665810
V-LOVKAFE — Mood & Libido Support Coffee (8 citations)
[1] A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction.
Dording CM, Fisher L, Papakostas G et al. · CNS neuroscience & therapeutics · 2008
We sought to determine whether maca, a Peruvian plant, is effective for selective-serotonin reuptake inhibitor (SSRI)-induced sexual dysfunction. We conducted a double-blind, randomized, parallel grou...
PubMed PMID: 18801111
[2] Tribulus terrestris versus placebo in the treatment of erectile dysfunction: A prospective, randomized, double blind study.
Santos CA, Reis LO, Destro-Saade R et al. · Actas urologicas espanolas · 2014
To evaluate the possible effects of Tribulus terrestris herbal medicine in the erectile dysfunction treatment and to quantify its potential impact on serum testosterone levels.
PubMed PMID: 24630840
[3] Efficacy of Tribulus Terrestris for the treatment of premenopausal women with hypoactive sexual desire disorder: a randomized double-blinded, place...
Vale FBC, Zanolla Dias de Souza K, Rezende CR et al. · Gynecological endocrinology : the official journal of the... · 2018
Although hypoactive sexual desire disorder (HSDD) is the most common sexual complaint, there is no consensus for the ideal treatment. Our study aimed to evaluate the efficacy of treating premenopausal...
PubMed PMID: 29172782
[4] An Examination into the Effects of a Saffron Extract (Affron) on Mood and General Wellbeing in Adults Experiencing Low Mood: A Randomized, Double-B...
Lopresti AL, Smith SJ, Marx W et al. · The Journal of nutrition · 2025
Saffron, derived from the stigmas of the Crocus sativus flower, has been shown in previous trials to have antidepressant effects in clinically diagnosed adults. However, the recruitment of small sampl...
PubMed PMID: 40414301
[5] Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-con...
Amadieu C, Leyrolle Q, Farneti M et al. · The American journal of clinical nutrition · 2025
Subclinical depressive symptoms, including low mood, fatigue and anxiety, refer to clinically relevant depressive manifestations that do not meet the criteria for major depressive disorder. These symp...
PubMed PMID: 41047129
[6] Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
Panossian A, Wikman G, Sarris J · Phytomedicine : international journal of phytotherapy and... · 2010
The aim of this review article was to summarize accumulated information related to chemical composition, pharmacological activity, traditional and official use of Rhodiola rosea L. in medicine. In tot...
PubMed PMID: 20378318
[7] Rhodiola rosea: A Versatile Adaptogen.
Khanum F, Bawa AS, Singh B · Comprehensive reviews in food science and food safety · 2005
Rhodiola rosea (rose root) belonging to the family Crassulaceae is a popular medicinal plant in Russia, Scandinavia, and many other countries. Extracts of the roots of this plant have been found to fa...
PubMed PMID: 33430554
[8] Cyrcadian Rhythm, Mood, and Temporal Patterns of Eating Chocolate: A Scoping Review of Physiology, Findings, and Future Directions.
Garbarino S, Garbarino E, Lanteri P · Nutrients · 2022
This paper discusses the effect of chrononutrition on the regulation of circadian rhythms; in particular, that of chocolate on the resynchronization of the human internal biological central and periph...
PubMed PMID: 35956290
V-THERMOKAFE — Thermogenic Metabolism Coffee (9 citations)
[1] Dietary Supplements for Weight Management: A Narrative Review of Safety and Metabolic Health Benefits.
Mah E, Chen O, Liska DJ et al. · Nutrients · 2022
Dietary supplements for weight management include myriad ingredients with thermogenic, lipotropic, satiety, and other metabolic effects. Recently, the safety of this product category has been question...
PubMed PMID: 35565754
[2] Effects of green tea extracts on non-shivering thermogenesis during mild cold exposure in young men.
Gosselin C, Haman F · The British journal of nutrition · 2013
The effects of epigallocatechin-3-gallate (EGCG) and caffeine on non-shivering thermogenesis (NST) during cold exposure is unknown. The purpose of the present study was to quantify the effects of co-i...
PubMed PMID: 23237788
[3] The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis.
Hursel R, Viechtbauer W, Dulloo AG et al. · Obesity reviews : an official journal of the Internationa... · 2011
Different outcomes of the effect of catechin-caffeine mixtures and caffeine-only supplementation on energy expenditure and fat oxidation have been reported in short-term studies. Therefore, a meta-ana...
PubMed PMID: 21366839
[4] A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, and Cognitive Performance.
Krieger J, Schrautemeier A, Hagele A et al. · Nutrients · 2025
PubMed PMID: 41374082
[5] Thermogenic ingredients and body weight regulation.
Hursel R, Westerterp-Plantenga MS · International journal of obesity (2005) · 2010
The global prevalence of obesity has increased considerably in the last decade. Tools for obesity management, including consumption of caffeine, capsaicin and different teas such as green, white and o...
PubMed PMID: 20142827
[6] Capsaicinoids: a spicy solution to the management of obesity?
Tremblay A, Arguin H, Panahi S · International journal of obesity (2005) · 2016
Capsaicin is the molecule that is responsible for the pungency of hot peppers. It stimulates the sympathoadrenal system that mediates the thermogenic and anorexigenic effects of capsaicinoids. Capsaic...
PubMed PMID: 26686003
[7] Chlorogenic acid in green bean coffee on body weight: a systematic review and meta-analysis of randomized controlled trials.
Kanchanasurakit S, Saokaew S, Phisalprapa P et al. · Systematic reviews · 2023
Supplemental green bean coffee extract (GBCE) with caffeine has been shown to prevent weight gain. There are different dosages of GBCE that contain chlorogenic acid (CGA), and the data for their effec...
PubMed PMID: 37710316
[8] Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-B...
Nederveen JP, Mastrolonardo AJ, Xhuti D et al. · Nutrients · 2023
Despite the growing recognition of the obesity crisis, its rates continue to rise. The current first-line therapies, such as dietary changes, energy restriction, and physical activity, are typically m...
PubMed PMID: 37686725
[9] Chronic Thermogenic Dietary Supplement Consumption: Effects on Body Composition, Anthropometrics, and Metabolism.
Siedler MR, Rodriguez C, White SJ et al. · Nutrients · 2023
Multi-ingredient thermogenic supplements can acutely increase resting energy expenditure (REE) and subjective energy. However, less is understood about the effects of chronic consumption on body compo...
PubMed PMID: 38004200
LATTEKAFFE — Functional Latte Coffee Blend (6 citations)
[1] Polyphenols: Chemistry, bioavailability, bioactivity, nutritional aspects and human health benefits: A review.
El-Saadony MT, Yang T, Saad AM et al. · International journal of biological macromolecules · 2024
Polyphenols, including phenolics, alkaloids, and terpenes, are secondary metabolites that are commonly found in fruits, vegetables, and beverages, such as tea, coffee, wine, chocolate, and beer. These...
PubMed PMID: 39084416
[2] Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management.
Alkhatib A, Tsang C, Tiss A et al. · Nutrients · 2017
Functional foods contain biologically active ingredients associated with physiological health benefits for preventing and managing chronic diseases, such as type 2 diabetes mellitus (T2DM). A regular ...
PubMed PMID: 29194424
[3] Medium-chain fatty acids for the prevention or treatment of Alzheimer's disease: a systematic review and meta-analysis.
Castro CB, Dias CB, Hillebrandt H et al. · Nutrition reviews · 2023
In preclinical Alzheimer's disease (AD), the brain gradually becomes insulin resistant. As a result, brain glucose utilization is compromised, causing a cellular energy deficit that leads to the accum...
PubMed PMID: 36633304
[4] Ketogenic therapies in Parkinson's disease, Alzheimer's disease, and mild cognitive impairment: An integrative review.
Price S, Ruppar TM · Applied nursing research : ANR · 2023
Ketogenic therapies have shown benefit for seizure reduction in epilepsy but their impact on other neurologic conditions is less known. In this literature review, the efficacy of ketogenic therapies w...
PubMed PMID: 38007248
[5] Coffee pulp supplement affects antioxidant status and favors anti-aging of skin in healthy subjects.
Tseng YP, Liu C, Chan LP et al. · Journal of cosmetic dermatology · 2022
Coffee and coffee products are known potentially to reduce levels of oxidative stress biomarkers in humans.
PubMed PMID: 34265165
[6] Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
Duangjai A, Srivilai J, Nangola S et al. · Clinics and practice · 2025
Menopause leads to estrogen deficiency, which negatively affects bone density, skin integrity, and hair health in women. This study aimed to evaluate the effects of fish-derived collagen peptides, cal...
PubMed PMID: 41002783
S-BALANCE — Gut Microbiome Balance (10 citations)
[1] The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids.
Xiao W, Su J, Gao X et al. · Microbiome · 2022
Chronic cerebral hypoperfusion (CCH) underlies secondary brain injury following certain metabolic disorders and central nervous system (CNS) diseases. Dysregulation of the microbiota-gut-brain axis ca...
PubMed PMID: 35430804
[2] Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood.
Perdijk O, Butler A, Macowan M et al. · Immunity · 2024
Antibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice given antibiotics in early life (EL-Abx), but not in adultho...
PubMed PMID: 39013465
[3] The Gut Microbiome of Dogs and Cats, and the Influence of Diet.
Pilla R, Suchodolski JS · The Veterinary clinics of North America. Small animal pra... · 2021
The gut microbiome is a functional organ, and responds metabolically to the nutrient composition within the diet. Fiber, starch, and protein content have strong effects on the microbiome composition, ...
PubMed PMID: 33653538
[4] The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components.
Xiong RG, Li J, Cheng J et al. · Nutrients · 2023
The number of individuals experiencing mental disorders (e.g., anxiety and depression) has significantly risen in recent years. Therefore, it is essential to seek prevention and treatment strategies f...
PubMed PMID: 37513676
[5] AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insufficiency: Expert Review.
Whitcomb DC, Buchner AM, Forsmark CE · Gastroenterology · 2023
Exocrine pancreatic insufficiency (EPI) is a disorder caused by the failure of the pancreas to deliver a minimum/threshold level of specific pancreatic digestive enzymes to the intestine, leading to t...
PubMed PMID: 37737818
[6] Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management.
Misselwitz B, Butter M, Verbeke K et al. · Gut · 2019
Lactose is the main source of calories in milk, an essential nutriedigestion, patients with visceral hypersensitivity nt in infancy and a key part of the diet in populations that maintain the ability ...
PubMed PMID: 31427404
[7] Probiotics.
Williams NT · American journal of health-system pharmacy : AJHP : offic... · 2010
The pharmacology, uses, dosages, safety, drug interactions, and contraindications of probiotics are reviewed.
PubMed PMID: 20208051
[8] Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review.
Gopalan S, Ganapathy S, Mitra M et al. · Cureus · 2023
Probiotics, both bacterial and yeast, have long been associated with a beneficial health history and human well-being. Among yeasts,
PubMed PMID: 37927652
[9] Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders.
Verma A, Inslicht SS, Bhargava A · Cells · 2024
The influence of gut microbiome, metabolites, omics, hormones, and stress on general and mental health is increasingly being recognized. Ancient cultures recognized the importance of diet and gut heal...
PubMed PMID: 39273008
[10] Diet and the Microbiota-Gut-Brain Axis: Sowing the Seeds of Good Mental Health.
Berding K, Vlckova K, Marx W et al. · Advances in nutrition (Bethesda, Md.) · 2021
Over the past decade, the gut microbiota has emerged as a key component in regulating brain processes and behavior. Diet is one of the major factors involved in shaping the gut microbiota composition ...
PubMed PMID: 33693453
V-TEDETOX — Herbal Detox Tea (6 citations)
[1] Effect of kombucha intake on the gut microbiota and obesity-related comorbidities: A systematic review.
Costa MAC, Vilela DLS, Fraiz GM et al. · Critical reviews in food science and nutrition · 2023
Kombucha is a fermented nonalcoholic tea-based beverage produced through a symbiotic culture of bacteria and yeasts.
PubMed PMID: 34698580
[2] Kombucha as a Health-Beneficial Drink for Human Health.
Massoud R, Jafari R, Khosravi-Darani K · Plant foods for human nutrition (Dordrecht, Netherlands) · 2024
Kombucha is a unique fermented beverage made from a symbiotic culture of yeast and bacteria. Kombucha is normally based on black tea added to water, then sugar is added as a substrate for fermentation...
PubMed PMID: 38602651
[3] Pre-administration of super-low volume polyethylene glycol is as effective as senna laxative as bowel preparation for colonoscopy: a randomized con...
Ishibashi F, Tanaka R, Sugihara K et al. · Surgical endoscopy · 2022
Senna laxatives are commonly used for bowel preparation before colonoscopies in Japan. However, this laxative frequently causes complications such as abdominal pain. This study aimed to establish a no...
PubMed PMID: 34159460
[4] Efficacy of 1 L Polyethylene Glycol Plus Ascorbic Acid With Linaclotide Versus Senna for Bowel Preparation: A Multicenter, Endoscopist-Blinded, Ran...
Maeda N, Higashimori A, Kabata D et al. · The American journal of gastroenterology · 2025
No bowel preparation (BP) for colonoscopy achieves optimal efficacy and tolerability. Combining polyethylene glycol plus ascorbic acid (PEG-Asc) with adjuvants has been explored to enhance cleansing e...
PubMed PMID: 39996602
[5] Health Benefits and Chemical Composition of Matcha Green Tea: A Review.
Kochman J, Jakubczyk K, Antoniewicz J et al. · Molecules (Basel, Switzerland) · 2020
Japanese matcha is a type of powdered green tea, grown in a traditional way. Shading of the plants during the growth period enhances the processes of synthesis and accumulation of biologically active ...
PubMed PMID: 33375458
[6] Health benefits of polyphenols: A concise review.
Rana A, Samtiya M, Dhewa T et al. · Journal of food biochemistry · 2022
Plants produce polyphenols, which are considered highly essential functional foods in our diet. They are classified into several groups according to their diverse chemical structures. Flavanoids, lign...
PubMed PMID: 35694805
NOURISH+ — Plant-Based Superfood Blend (6 citations)
[1] Benefits of a plant-based diet and considerations for the athlete.
Shaw KA, Zello GA, Rodgers CD et al. · European journal of applied physiology · 2022
Individuals may opt to follow a plant-based diet for a variety of reasons, such as religious practices, health benefits or concerns for animal or environmental welfare. Such diets offer a broad spectr...
PubMed PMID: 35150294
[2] Position of the Academy of Nutrition and Dietetics: Vegetarian Diets.
Melina V, Craig W, Levin S · Journal of the Academy of Nutrition and Dietetics · 2016
It is the position of the Academy of Nutrition and Dietetics that appropriately planned vegetarian, including vegan, diets are healthful, nutritionally adequate, and may provide health benefits for th...
PubMed PMID: 27886704
[3] In vitro and in vivo antioxidant potential of milks, yoghurts, fermented milks and cheeses: a narrative review of evidence.
Fardet A, Rock E · Nutrition research reviews · 2018
The antioxidant potential (AP) is an important nutritional property of foods, as increased oxidative stress is involved in most diet-related chronic diseases. In dairy products, the protein fraction c...
PubMed PMID: 28965518
[4] A Green Bioactive By-Product Almond Skin Functional Extract for Developing Nutraceutical Formulations with Potential Antimetabolic Activity.
Picerno P, Crascì L, Iannece P et al. · Molecules (Basel, Switzerland) · 2023
(1) Background: almond peels are rich in polyphenols such as catechin and epicatechin, which are important anti-free-radical agents, anti-inflammatory compounds, and capable of breaking down cholester...
PubMed PMID: 38067642
[5] Global estimation of dietary micronutrient inadequacies: a modelling analysis.
Passarelli S, Free CM, Shepon A et al. · The Lancet. Global health · 2024
Inadequate micronutrient intakes and related deficiencies are a major challenge to global public health. Analyses over the past 10 years have assessed global micronutrient deficiencies and inadequate ...
PubMed PMID: 39218000
[6] Effective interventions to address maternal and child malnutrition: an update of the evidence.
Keats EC, Das JK, Salam RA et al. · The Lancet. Child & adolescent health · 2021
Malnutrition-consisting of undernutrition, overweight and obesity, and micronutrient deficiencies-continues to afflict millions of women and children, particularly in low-income and middle-income coun...
PubMed PMID: 33691083
PERFORMANCE+ — Sports Nutrition Complex (10 citations)
[1] Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations.
Wax B, Kerksick CM, Jagim AR et al. · Nutrients · 2021
Creatine is one of the most studied and popular ergogenic aids for athletes and recreational weightlifters seeking to improve sport and exercise performance, augment exercise training adaptations, and...
PubMed PMID: 34199588
[2] Creatine supplementation improves performance, but is it safe? Double-blind placebo-controlled study.
Almeida D, Colombini A, Machado M · The Journal of sports medicine and physical fitness · 2020
Creatine represents a natural supplement and ergogenic aid for sport performance, but there are several concerns regarding its safety for health. The present double-blind placebo-controlled study eval...
PubMed PMID: 32597619
[3] Role of beta-alanine supplementation on muscle carnosine and exercise performance.
Artioli GG, Gualano B, Smith A et al. · Medicine and science in sports and exercise · 2010
In this narrative review, we present and discuss the current knowledge available on carnosine and beta-alanine metabolism as well as the effects of beta-alanine supplementation on exercise performance...
PubMed PMID: 20479615
[4] β-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis.
Saunders B, Elliott-Sale K, Artioli GG et al. · British journal of sports medicine · 2017
To conduct a systematic review and meta-analysis of the evidence on the effects of β-alanine supplementation on exercise capacity and performance.
PubMed PMID: 27797728
[5] Advances in muscle health and nutrition: A toolkit for healthcare professionals.
Prado CM, Landi F, Chew STH et al. · Clinical nutrition (Edinburgh, Scotland) · 2022
Low muscle mass and malnutrition are prevalent conditions among adults of all ages, with any body weight or body mass index, and with acute or chronic conditions, including COVID-19. This article synt...
PubMed PMID: 36081299
[6] Personalized nutrition therapy in critical care: 10 expert recommendations.
Wischmeyer PE, Bear DE, Berger MM et al. · Critical care (London, England) · 2023
Personalization of ICU nutrition is essential to future of critical care. Recommendations from American/European guidelines and practice suggestions incorporating recent literature are presented. Low-...
PubMed PMID: 37403125
[7] American College of Sports Medicine position stand. Nutrition and athletic performance.
Unknown Authors et al. · Medicine and science in sports and exercise · 2009
It is the position of the American Dietetic Association, Dietitians of Canada, and the American College of Sports Medicine that physical activity, athletic performance, and recovery from exercise are ...
PubMed PMID: 19225360
[8] Position of the American Dietetic Association, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and athletic performance.
Rodriguez NR, DiMarco NM, Langley S et al. · Journal of the American Dietetic Association · 2009
It is the position of the American Dietetic Association, Dietitians of Canada, and the American College of Sports Medicine that physical activity, athletic performance, and recovery from exercise are ...
PubMed PMID: 19278045
[9] International society of sports nutrition position stand: caffeine and exercise performance.
Guest NS, VanDusseldorp TA, Nelson MT et al. · Journal of the International Society of Sports Nutrition · 2021
Following critical evaluation of the available literature to date, The International Society of Sports Nutrition (ISSN) position regarding caffeine intake is as follows: 1. Supplementation with caffei...
PubMed PMID: 33388079
[10] International society of sports nutrition position stand: nutrient timing.
Kerksick CM, Arent S, Schoenfeld BJ et al. · Journal of the International Society of Sports Nutrition · 2017
The International Society of Sports Nutrition (ISSN) provides an objective and critical review regarding the timing of macronutrients in reference to healthy, exercising adults and in particular highl...
PubMed PMID: 28919842
SMARTBIOTICS KIDS — Children's Probiotic (8 citations)
[1] Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms.
Sanctuary MR, Kain JN, Chen SY et al. · PloS one · 2019
Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these s...
PubMed PMID: 30625189
[2] How Probiotics Affect the Microbiota.
Wieërs G, Belkhir L, Enaud R et al. · Frontiers in cellular and infection microbiology · 2019
Probiotics have been used to treat a variety of diseases for decades; however, what is the rationale for their application? Such a treatment was first proposed in the early nineteenth century based on...
PubMed PMID: 32010640
[3] Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial.
Lukasik J, Dierikx T, Besseling-van der Vaart I et al. · JAMA pediatrics · 2022
The efficacy of multispecies probiotic formulations in the prevention of antibiotic-associated diarrhea (AAD) remains unclear.
PubMed PMID: 35727573
[4] Association Between Diarrhea Duration and Severity and Probiotic Efficacy in Children With Acute Gastroenteritis.
Schnadower D, O'Connell KJ, VanBuren JM et al. · The American journal of gastroenterology · 2021
It is unclear whether the alleged efficacy of probiotics in childhood acute gastroenteritis depends on the duration and severity of symptoms before treatment.
PubMed PMID: 34183579
[5] The Impact of Formula Choice for the Management of Pediatric Cow's Milk Allergy on the Occurrence of Other Allergic Manifestations: The Atopic Marc...
Nocerino R, Bedogni G, Carucci L et al. · The Journal of pediatrics · 2021
To compare the impact of different formulas on the occurrence of other atopic manifestations and the time of immune tolerance acquisition.
PubMed PMID: 33524387
[6] Skin as the target for allergy prevention and treatment.
Marques-Mejias A, Bartha I, Ciaccio CE et al. · Annals of allergy, asthma & immunology : official publica... · 2024
The fact that genetic and environmental factors could trigger disruption of the epithelial barrier and subsequently initiate a T
PubMed PMID: 38253125
[7] Temporal development of the gut microbiome in early childhood from the TEDDY study.
Stewart CJ, Ajami NJ, O'Brien JL et al. · Nature · 2018
The development of the microbiome from infancy to childhood is dependent on a range of factors, with microbial-immune crosstalk during this time thought to be involved in the pathobiology of later lif...
PubMed PMID: 30356187
[8] Gut microbiome and breast-feeding: Implications for early immune development.
Davis EC, Castagna VP, Sela DA et al. · The Journal of allergy and clinical immunology · 2022
Establishment of the gut microbiome during early life is a complex process with lasting implications for an individual's health. Several factors influence microbial assembly; however, breast-feeding i...
PubMed PMID: 36075638
D-FENZ KIDS — Children's Immune Defense (6 citations)
[1] Immune-enhancing role of vitamin C and zinc and effect on clinical conditions.
Wintergerst ES, Maggini S, Hornig DH · Annals of nutrition & metabolism · 2006
Vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress. Supplementation of vitamin C was found to improve components of the human immune system such as anti...
PubMed PMID: 16373990
[2] The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19.
Cerullo G, Negro M, Parimbelli M et al. · Frontiers in immunology · 2020
From Pauling's theories to the present, considerable understanding has been acquired of both the physiological role of vitamin C and of the impact of vitamin C supplementation on the health. Although ...
PubMed PMID: 33193359
[3] The transcription factor ZEB2 drives the formation of age-associated B cells.
Dai D, Gu S, Han X et al. · Science (New York, N.Y.) · 2024
Age-associated B cells (ABCs) accumulate during infection, aging, and autoimmunity, contributing to lupus pathogenesis. In this study, we screened for transcription factors driving ABC formation and f...
PubMed PMID: 38271512
[4] Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity.
Zhou L, Lian G, Zhou T et al. · Nature cancer · 2025
Ferroptosis is closely linked with various pathophysiological processes, including aging, neurodegeneration, ischemia-reperfusion injury, viral infection and, notably, cancer progression; however, its...
PubMed PMID: 40108413
[5] An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases.
Sîrbe C, Rednic S, Grama A et al. · International journal of molecular sciences · 2022
Vitamin D intervenes in calcium and phosphate metabolism and bone homeostasis. Experimental studies have shown that 1,25-dihydroxyvitamin D (calcitriol) generates immunologic activities on the innate ...
PubMed PMID: 36077185
[6] Vitamin D and health - The missing vitamin in humans.
Chang SW, Lee HC · Pediatrics and neonatology · 2019
Severe vitamin D deficiency may cause rickets in infants or children and osteomalacia in adults, though it is now uncommon in developed countries. However, subclinical vitamin D deficiency is more pre...
PubMed PMID: 31101452
GENIUS SHAKE KIDS — Children's Brain & Growth Nutrition (8 citations)
[1] Maternal nutrition and its effects on fetal neurodevelopment.
Reis ÁEM, Teixeira IS, Maia JM et al. · Nutrition (Burbank, Los Angeles County, Calif.) · 2024
Herein, we present a thorough examination of the impact of maternal nutrition on fetal and infant neurodevelopment, focusing on specific nutrients and their critical roles in perinatal and pediatric h...
PubMed PMID: 38823254
[2] Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impu...
Patrick RP, Ames BN · FASEB journal : official publication of the Federation of... · 2015
Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize previous findings that serotonin regulates executive function, sensory gating, and social behavior and that att...
PubMed PMID: 25713056
[3] Effectiveness of intermittent iron and high-dose vitamin A supplementation on cognitive development of school children in southern Ethiopia: a rand...
Gutema BT, Levecke B, Sorrie MB et al. · The American journal of clinical nutrition · 2024
Iron is an essential mineral whose deficiency results in cognitive alteration, impaired emotional behaviors, and altered myelination and neurotransmission. In animal models, it has been shown that vit...
PubMed PMID: 37952928
[4] Iron and Cognitive Development: What Is the Evidence?
Larson LM, Phiri KS, Pasricha SR · Annals of nutrition & metabolism · 2017
The theoretical irreversible damage that iron deficiency and iron deficiency anemia can exert on child development makes a compelling argument for action to alleviate the burden. However, a critical a...
PubMed PMID: 29268256
[5] Nutrition and growth in children.
Matonti L, Blasetti A, Chiarelli F · Minerva pediatrica · 2020
The well-balanced nourishment during "the first 1000 days," the period between conception (day 18) and the age of two years, is quite important for two main reasons. Firstly, the nutritive requirement...
PubMed PMID: 32731734
[6] Influence of Nutrition on Growth and Development of Metabolic Syndrome in Children.
Quarta A, Quarta MT, Mastromauro C et al. · Nutrients · 2024
Obesity is currently an increasing public health burden due to its related metabolic and cardiovascular complications. In Western countries, a significant number of people are overweight or obese, and...
PubMed PMID: 39599588
[7] Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
Obeid R, Derbyshire E, Schön C · Advances in nutrition (Bethesda, Md.) · 2022
We studied associations between prenatal and early postnatal choline intake, brain development, and neurocognitive function of children. We conducted a systematic review followed by a meta-analysis an...
PubMed PMID: 36041182
[8] Choline: essential for brain development and function.
Zeisel SH · Advances in pediatrics · 1997
Pregnancy and lactation are periods when maternal reserves of choline are depleted. At the same time, the availability of choline for normal development of brain is critical. Variations in choline int...
PubMed PMID: 9265973